|
【结 构 式】 
|
【分子编号】24095 【品名】(2R,3S)-2,3,6-trichloro-2,3-dihydro-1,4-naphthalenedione 【CA登记号】 |
【 分 子 式 】C10H5Cl3O2 【 分 子 量 】263.5066 【元素组成】C 45.58% H 1.91% Cl 40.36% O 12.14% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The chlorination of 6-choro-1,4-naphthoquinone (I) with Cl2 in acetic acid gives 2,3,6-trichloro-2,3-dihydro-1,4-naphthoquinone (II), which is treated with sodium acetate and Cl2 in refluxing acetic acid yielding 2,3,6-trichloro-1,4-naphthoquinone (II) The reaction of (III) with sodium methoxide in reftuxing methanol affords 6-chloro-2,3-dimethoxy-1-4-naphthoquinone (IV), which is finally reduced with H2 over Pd/C IP THF, and acetylated with acetic anhydride in pyridine (I).
| 【1】 Jones, G.H.; Venuti, M.C.; Young, J.M. (Syntex (USA), Inc.); 1,4-Acyloxynaphthalene derivs., topical compsns. containing them, methods for their preparation, and intermediates therefor. EP 0107512; US 4466981 . |
| 【2】 Castaner, J.; Prous, J.; RS-43179. Drugs Fut 1986, 11, 1, 34. |
Extended Information