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【结 构 式】

【分子编号】24017

【品名】N-(cyclohexylcarbonyl)alanine

【CA登记号】

【 分 子 式 】C10H17NO3

【 分 子 量 】199.24992

【元素组成】C 60.28% H 8.6% N 7.03% O 24.09%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

The reaction of N-(cyclohexanecarbonyl)-D-alanine (I) with 3-mercapto-2-methylpropanoic acid (II) by means of carbonyldiimidazole (III) in THF gives 3-[N-(cyclohexanecarbonyl)-D alanilthio]-2-methyl-propanoic acid (IV), which is then condensed with L-protine (V) by means of triethylamine and ethyl chloroformate (VI) o THF.

1 Iwaoka, T.; Kuromaru, K.; Obatake, N.; Hata, S.I.; Matsunaga, I.; Fujimura, Y.; Aono, J.; Hinohara, Y.; Fukushima, M.; Nabata, H.; Sakai, K.; Tanaka, S.; Nakano, H. (Chugai Pharmaceutical Co. Ltd.); Proline derivative. BE 0893553; JP 1982209270; JP 1988045252 .
2 Prous, J.; Castaner, J.; MC-838. Drugs Fut 1986, 11, 5, 380.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 24017 N-(cyclohexylcarbonyl)alanine C10H17NO3 详情 详情
(II) 24018 2-methyl-3-sulfanylpropionic acid 26473-47-2 C4H8O2S 详情 详情
(III) 11353 1,1'-Carbonyldiimidazole; Di(1H-imidazol-1-yl)methanone; N,N-Carbonyldiimidazole; 1,1'-Carbonylbis(1H-imidazole) 530-62-1 C7H6N4O 详情 详情
(IV) 24020 3-([2-[(cyclohexylcarbonyl)amino]propanoyl]sulfanyl)-2-methylpropionic acid C14H23NO4S 详情 详情
(V) 16731 L-proline 147-85-3 C5H9NO2 详情 详情
Extended Information