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【结 构 式】 
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【分子编号】24006 【品名】1,2-dichloro-3-iodobenzene 【CA登记号】2401-21-0 |
【 分 子 式 】C6H3Cl2I 【 分 子 量 】272.89969 【元素组成】C 26.41% H 1.11% Cl 25.98% I 46.5% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The Grignard condensation of 2,3-dichloroiodobenzene (I) with CO2 by means of Mg / ether gives 2,3-dichlorobenzoic acid (II), which is converted to the corresponding acyl chloride (III) by refluxing with SOCl2.The reaction of (III) with cuprous cyanide and KI in refluxing xylene yields 2,3-dichlorobenzoyl cyanide (IV). Finally, this compound is cyclized with aminoguanidine (V) in DMSO.
| 【1】 Baxter, M.G.; Elphick, A.R.; Miller, A.A.; Sawyer, D.A. (Glaxo Wellcome plc); 1,2,4-Triazine derivs., process for preparing such cpds., pharmaceutical compsns. and intermediates utilized for this process. CA 1133938; EP 0021121 . |
| 【2】 Castaner, J.; Prous, J.; Lamotrigine. Drugs Fut 1986, 11, 6, 456. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 24006 | 1,2-dichloro-3-iodobenzene | 2401-21-0 | C6H3Cl2I | 详情 | 详情 |
| (II) | 24007 | 2,3-dichlorobenzoic acid | 50-45-3 | C7H4Cl2O2 | 详情 | 详情 |
| (III) | 24008 | 2,3-dichlorobenzoyl chloride | 2905-60-4 | C7H3Cl3O | 详情 | 详情 |
| (IV) | 24009 | 2-(2,3-dichlorophenyl)-2-oxoacetonitrile; 2,3-Dichlorobenzoylcyanide | 77668-42-9 | C8H3Cl2NO | 详情 | 详情 |
| (V) | 10015 | 1-Hydrazinecarboximidamide; Hydrazinecarboximidamide | 79-17-4 | CH6N4 | 详情 | 详情 |
Extended Information