4-Methyl-3-(3-nitrobenzamido)-N-(4,6,8-trisulfonaphthalen-1-yl)benzamide trisodium salt -Drug Synthesis Database

【结构式】

【分子编号】23918

【品名】4-Methyl-3-(3-nitrobenzamido)-N-(4,6,8-trisulfonaphthalen-1-yl)benzamide trisodium salt

【CA登记号】

【分子式】C₂₅H₁₆N₃Na₃O₁₃S₃

【分子量】731.581764

【元素组成】C 41.04% H 2.2% N 5.74% Na 9.43% O 28.43% S 13.15%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VI)

Several procedures for obtaining titte compound have been reported: In one method the acylation of 1 naphthylamine 4,6,8-trisulfonic acid trisodium salt (I) with 4 methyl-3-nitrobenzoyt chloride (II) yields the correspond ing amide (III), which is reduced with Fe in acetic acid to the amine (IV). Acylation of (IV) with 3-nitrobenzoyl chloride (V) affords the nitro diamide (VI), which is reduced with Fe and acetic acid before to the amine (VII). Finally, this compound is condensed with phosgene.

参考文献中间体

合成目标

【1】 Heymann; Angew Chem 1924, 37, 585.
【2】 Freres, P.; Foruneau, E.; Trefouel, J.; The manufacture of a symmetrical urea of m-aminobenzoyl-m-aminomethylbenzoyl-1-napthylamino-4,6,8-trisulphonate of sodium. GB 224849 .
【3】 Fourneau; et al.; Compt Rend Acad Sci 1924, 178, 675.
【4】 Castaner, J.; Serradell, M.N.; Suramin Sodium. Drugs Fut 1986, 11, 10, 860.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	23913	8-Aminonaphthalene-1,3,5-trisulfonic acid trisodium salt		C₁₀H₆NNa₃O₉S₃	详情	详情
(II)	23914	4-methyl-3-nitrobenzoyl chloride	10397-30-5	C₈H₆ClNO₃	详情	详情
(III)	23915	4-Methyl-3-nitro-N-(4,6,8-trisulfonaphthalen-1-yl)benzamide trisodium salt		C₁₈H₁₁N₂Na₃O₁₂S₃	详情	详情
(IV)	23916	3-Amino-4-methyl-N-(4,6,8-trisulfonaphthalen-1-yl)benzamide trisodium salt		C₁₈H₁₃N₂Na₃O₁₀S₃	详情	详情
(V)	15293	3-nitrobenzoyl chloride; m-nitrobenzoyl chloride	121-90-4	C₇H₄ClNO₃	详情	详情
(VI)	23918	4-Methyl-3-(3-nitrobenzamido)-N-(4,6,8-trisulfonaphthalen-1-yl)benzamide trisodium salt		C₂₅H₁₆N₃Na₃O₁₃S₃	详情	详情
(VII)	23919	3-(3-Aminobenzamido)-4-methyl-N-(4,6,8-trisulfonaphthalen-1-yl)benzamide trisodium salt		C₂₅H₁₈N₃Na₃O₁₁S₃	详情	详情

Extended Information