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【结 构 式】 
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【分子编号】23816 【品名】N-(2-bromo-4,6-dimethoxyphenyl)-N-(4-chloro-6-methyl-1,3,5-triazin-2-yl)amine; N-(2-bromo-4,6-dimethoxyphenyl)-4-chloro-6-methyl-1,3,5-triazin-2-amine 【CA登记号】 |
【 分 子 式 】C12H12BrClN4O2 【 分 子 量 】359.60974 【元素组成】C 40.08% H 3.36% Br 22.22% Cl 9.86% N 15.58% O 8.9% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Treatment of cyanuric chloride (I) with methylmagnesium chloride afforded 2,4-dichloro-6-methyltriazine (II), which was condensed with aniline (III) to produce the anilinotriazine (IV). Subsequent displacement of the remaining chlorine atom of (IV) with morpholine (V) provided (VI). The target compound was then obtained by N-alkylation with iodoethane in the presence of NaH, followed by conversion to the methanesulfonate salt).
| 【1】 Arvanitis, A.G.; Chorvat, R.J.; Gilligan, P.J.; et al.; Non-peptide corticotropin-releasing hormone antago. J Med Chem 1999, 42, 5, 805. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 23813 | 2,4,6-Trichloro-s-triazine; Cyanuric chloride; Trichlorocyanidine; Tricyanogen chloride; 2,4,6-Trichloro-1,3,5-triazine | 108-77-0 | C3Cl3N3 | 详情 | 详情 |
| (II) | 23814 | 2,4-dichloro-6-methyl-1,3,5-triazine | C4H3Cl2N3 | 详情 | 详情 | |
| (III) | 23815 | 2-bromo-4,6-dimethoxyphenylamine; 2-bromo-4,6-dimethoxyaniline | C8H10BrNO2 | 详情 | 详情 | |
| (IV) | 23816 | N-(2-bromo-4,6-dimethoxyphenyl)-N-(4-chloro-6-methyl-1,3,5-triazin-2-yl)amine; N-(2-bromo-4,6-dimethoxyphenyl)-4-chloro-6-methyl-1,3,5-triazin-2-amine | C12H12BrClN4O2 | 详情 | 详情 | |
| (VI) | 23818 | N-(2-bromo-4,6-dimethoxyphenyl)-N-[4-methyl-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amine; N-(2-bromo-4,6-dimethoxyphenyl)-4-methyl-6-(4-morpholinyl)-1,3,5-triazin-2-amine | C16H20BrN5O3 | 详情 | 详情 | |
| (X) | 10388 | Morpholine | 110-91-8 | C4H9NO | 详情 | 详情 |
Extended Information