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【结 构 式】

【分子编号】23783

【品名】N(4)-(2-bromo-4-isopropylphenyl)-6-chloro-2-methyl-4,5-pyrimidinediamine; N-(5-amino-6-chloro-2-methyl-4-pyrimidinyl)-N-(2-bromo-4-isopropylphenyl)amine

【CA登记号】

【 分 子 式 】C14H16BrClN4

【 分 子 量 】355.6647

【元素组成】C 47.28% H 4.53% Br 22.47% Cl 9.97% N 15.75%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Condensation of 5-amino-4,6-dichloro-2-methylpyrimidine (I) and 2-bromo-4-isopropylaniline (II) in boiling ethoxyethanol gave diarylamine (III). Subsequent diazotization of (III) using NaNO2 and AcOH produced the triazolopyrimidine (IV), which was finally condensed with bis(2-methoxyethyl)amine (V) in the presence of Et3N in refluxing EtOH to provide the title compound.

1 Wilde, R.G.; Curry, M.; Cheeseman, R.S.; Bakthavatchalam, R.; Gilligan, P.J.; Hobbs, F.W.; Rescinito, J.P.; Chorvat, R.J.; Cocuzza, A.J.; Beck, J.P.; Synthesis, corticotropin-releasing factor receptor. J Med Chem 1999, 42, 5, 833.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 23537 4,6-dichloro-2-methyl-5-pyrimidinamine; 4,6-dichloro-2-methyl-5-pyrimidinylamine C5H5Cl2N3 详情 详情
(II) 23782 2-bromo-4-isopropylaniline; 2-bromo-4-isopropylphenylamine 51605-97-1 C9H12BrN 详情 详情
(III) 23783 N(4)-(2-bromo-4-isopropylphenyl)-6-chloro-2-methyl-4,5-pyrimidinediamine; N-(5-amino-6-chloro-2-methyl-4-pyrimidinyl)-N-(2-bromo-4-isopropylphenyl)amine C14H16BrClN4 详情 详情
(IV) 23784 3-(2-bromo-4-isopropylphenyl)-7-chloro-5-methyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine C14H13BrClN5 详情 详情
(V) 23785 N,N-bis(2-methoxyethyl)amine; 2-methoxy-N-(2-methoxyethyl)-1-ethanamine 111-95-5 C6H15NO2 详情 详情
Extended Information