|
【结 构 式】 
|
【分子编号】23594 【品名】1-(4-methoxy-2-nitrophenyl)-1H-pyrrole; methyl 3-nitro-4-(1H-pyrrol-1-yl)phenyl ether 【CA登记号】 |
【 分 子 式 】C11H10N2O3 【 分 子 量 】218.21208 【元素组成】C 60.55% H 4.62% N 12.84% O 22% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Phenyl pyrrole (III) was prepared by Clauson-Kaas reaction of 4-methoxy-2-nitroaniline (I) with 2,5-dimethoxytetrahydrofuran (II). Subsequent reduction of the nitro group of (III) using hydrazine and Raney Nickel provided aniline (IV), which was cyclized with phosgene in refluxing toluene to furnish the pyrroloquinoxaline (V). This was chlorinated with POCl3 to obtain the chloroquinoxaline (VI). Finally, nucleophilic substitution in (VI) with N-(4-fluorobenzyl)piperazine (VII) yielded the title compound.
| 【1】 Katounina, T.; et al.; Synthesis of [18F]MR 18445 and its in vivo evaluat. J Label Compd Radiopharm 1997, 40, 542. |
| 【2】 Lancelot, J.-C.; Prunier, H.; Rault, S.; et al.; Novel and selective partial agonists of 5-HT3 rece. J Med Chem 1997, 40, 12, 1808. |
| 【3】 Katounina, T.; et al.; Synthesis and biological investigations of [18F]MR. Bioorg Med Chem 1998, 6, 6, 789. |
| 【4】 Rault, S.; Lancelot, J.-C.; Prunier, H.; Robba, M.; Delagrange, P.; Renard, P.; Adam, G. (ADIR et Cie.); Pyrrolopyrazine derivs. with 5-HT3 activity. CA 2122890; EP 0623620; FR 2704547; JP 1994340666; US 5599812 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 23592 | 4-methoxy-2-nitrophenylamine; 4-methoxy-2-nitroaniline | 96-96-8 | C7H8N2O3 | 详情 | 详情 |
| (II) | 12132 | 2,5-Dimethoxytetrahydrofuran; 5-Methoxytetrahydro-2-furanyl methyl ether | 696-59-3 | C6H12O3 | 详情 | 详情 |
| (III) | 23594 | 1-(4-methoxy-2-nitrophenyl)-1H-pyrrole; methyl 3-nitro-4-(1H-pyrrol-1-yl)phenyl ether | C11H10N2O3 | 详情 | 详情 | |
| (IV) | 23595 | 5-methoxy-2-(1H-pyrrol-1-yl)phenylamine; 5-methoxy-2-(1H-pyrrol-1-yl)aniline | C11H12N2O | 详情 | 详情 | |
| (V) | 23596 | 7-methoxypyrrolo[1,2-a]quinoxalin-4(5H)-one | C12H10N2O2 | 详情 | 详情 | |
| (VI) | 23597 | 4-chloropyrrolo[1,2-a]quinoxalin-7-yl methyl ether; 4-chloro-7-methoxypyrrolo[1,2-a]quinoxaline | C12H9ClN2O | 详情 | 详情 | |
| (VII) | 23598 | 1-(4-fluorobenzyl)piperazine | C11H15FN2 | 详情 | 详情 |
Extended Information