7-hydroxy-4a,8a-dihydro-2(1H)-quinolinone -Drug Synthesis Database

【结构式】

【分子编号】23392

【品名】7-hydroxy-4a,8a-dihydro-2(1H)-quinolinone

【CA登记号】

【分子式】C₉H₉NO₂

【分子量】163.176

【元素组成】C 66.25% H 5.56% N 8.58% O 19.61%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The condensation of 7-hydroxycarbostyryl (I) with 1-bromo-3-chloropropane (II) by means of KOH in hot isopropranol gives 7-(3-chloropropoxy)carbostyryl (III), which is then allowed to react with 1-(2,3-dimethylpheny)piperazine (IV) by means of NaI and NaHCO3 in hot acetone.

参考文献中间体

合成目标

【1】 Banno, K.; Fujioka, T.; Nakagawa, K.; Oshiro, Y. (Otsuka Pharmaceutical Co., Ltd.); Pharmaceutically useful carbostyril derivs.. DE 2912105; FR 2421174; US 4734416 .
【2】 Prous, J.; Castaner, J.; OPC-4392. Drugs Fut 1988, 13, 10, 931.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	23392	7-hydroxy-4a,8a-dihydro-2(1H)-quinolinone		C₉H₉NO₂	详情	详情
(II)	10358	1-Bromo-3-chloropropane	109-70-6	C₃H₆BrCl	详情	详情
(III)	23394	7-(3-chloropropoxy)-4a,8a-dihydro-2(1H)-quinolinone		C₁₂H₁₄ClNO₂	详情	详情
(IV)	23395	1-(2,3-dimethylphenyl)piperazine	1013-22-5	C₁₂H₁₈N₂	详情	详情

Extended Information