【结 构 式】 |
【分子编号】23297 【品名】tert-butyl (1S,2S,4R)-1-[(2S)-2-[3-(benzyloxy)-4-methoxybenzyl]-3-methylbutyl]-5-(butylamino)-2-hydroxy-4-methyl-5-oxopentylcarbamate 【CA登记号】 |
【 分 子 式 】C35H54N2O6 【 分 子 量 】598.82364 【元素组成】C 70.2% H 9.09% N 4.68% O 16.03% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(XVI)Stereoselective hydrogenation of the methylene double bond of (XV) in the presence of a ruthenium chiral catalyst produced the (2R)-methyl compound (XVI). Further hydrogenolysis of the benzyl ether of (XVI) over Pd/C gave phenol (XVII), which was alkylated with 3-methoxypropyl iodide (XVIII) and NaH in DMF to yield ether (XIX). Finally, acid hydrolysis of the N-Boc protecting group of (XIX) furnished the title compound.
【1】 Rasetti, V.; Wood, J.; Grütter, M.; Maibaum, J.; Goeschke, R.; Cohen, N.C.; Fuhrer, W.; Rahuel, J.; Stutz, S.; Novel 2,7-dialkyl substituted 5(S)-amino-4(S)-hydr. 15th European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (Sept 6 1998, Edinburgh) 1998, Abst P.229. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(XV) | 23296 | tert-butyl (1S,2S)-1-[(2S)-2-[3-(benzyloxy)-4-methoxybenzyl]-3-methylbutyl]-4-[(butylamino)carbonyl]-2-hydroxy-4-pentenylcarbamate | C35H52N2O6 | 详情 | 详情 | |
(XVI) | 23297 | tert-butyl (1S,2S,4R)-1-[(2S)-2-[3-(benzyloxy)-4-methoxybenzyl]-3-methylbutyl]-5-(butylamino)-2-hydroxy-4-methyl-5-oxopentylcarbamate | C35H54N2O6 | 详情 | 详情 | |
(XVII) | 23298 | tert-butyl (1S,2S,4R)-5-(butylamino)-2-hydroxy-1-[(2S)-2-(3-hydroxy-4-methoxybenzyl)-3-methylbutyl]-4-methyl-5-oxopentylcarbamate | C28H48N2O6 | 详情 | 详情 | |
(XVIII) | 23299 | 1-iodo-3-methoxypropane; 3-iodopropyl methyl ether | C4H9IO | 详情 | 详情 | |
(XIX) | 23300 | tert-butyl (1S,2S,4R)-5-(butylamino)-2-hydroxy-1-[(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl]-4-methyl-5-oxopentylcarbamate | C32H56N2O7 | 详情 | 详情 |
Extended Information