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【结 构 式】

【分子编号】23261

【品名】4-[(5-bromo-2-pyrimidinyl)oxy]-3-chlorophenyl isocyanate; 5-bromo-2-(2-chloro-4-isocyanatophenoxy)pyrimidine

【CA登记号】

【 分 子 式 】C11H5BrClN3O2

【 分 子 量 】326.53642

【元素组成】C 40.46% H 1.54% Br 24.47% Cl 10.86% N 12.87% O 9.8%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

2) The reaction of aniline (III) with phosgene in ethyl acetate gives 4-(5-bromo-2-pyrimidinyloxy)-3-chlorophenyl isocyanate (V), which is then condensed with 2-nitrobenzamide (VI) in refluxing toluene.

1 Haga, T.; Kondo, N.; Koyanagi, T.; Nakajima, T.; Sugi, H.; Watanabe, M.; Yamada, N.; Yokoyama, K. (Ishihara Sangyo Kaisha, Ltd.); Benzoyl urea cpds., process for their production, . CH 671576; EP 0192235; FR 2577551; GB 2171695; US 4727077 .
2 Hoshi, A.; Prous, J.; Castaner, J.; HO-221. Drugs Fut 1988, 13, 9, 822.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 23256 2-Amino-4-chlorobenzoic acid; 4-Amino-2-chlorophenol 3964-52-1 C6H6ClNO 详情 详情
(II) 21054 5-bromo-2-chloropyrimidine C4H2BrClN2 详情 详情
(III) 23258 4-[(5-bromo-2-pyrimidinyl)oxy]-3-chlorophenylamine; 4-[(5-bromo-2-pyrimidinyl)oxy]-3-chloroaniline C10H7BrClN3O 详情 详情
(V) 23261 4-[(5-bromo-2-pyrimidinyl)oxy]-3-chlorophenyl isocyanate; 5-bromo-2-(2-chloro-4-isocyanatophenoxy)pyrimidine C11H5BrClN3O2 详情 详情
(VI) 23260 2-nitrobenzamide 610-15-1 C7H6N2O3 详情 详情
Extended Information