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【结 构 式】

【分子编号】23253

【品名】N-heptyl-4-neopentylbenzamide

【CA登记号】

【 分 子 式 】C19H31NO

【 分 子 量 】289.46128

【元素组成】C 78.84% H 10.79% N 4.84% O 5.53%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The reaction of 4-neopentylbenzoic acid (I) with SOCl2 in refluxing dichloromethane gives the corresponding acid chloride (II) , which is condensed with heptylamine (III) in dichloromethane to yield 4-neopentyl-N-heptylbenzamide (IV). The reduction of (IV) with di(2-methoxyethoxy)sodium aluminum hydride in refluxing toluene affords 4-neopentyl-N-heptylbenzylamine (V), which is finally condensed with 2,4-difluorophenyl isocyanate (VI) in hexane. Compound (II) can also be obtained from neopentylbenzene (VII) and oxalyl chloride in the presence of aluminum chloride.

1 Schaffer, S.A.; Dutia, M.D.; Largis, E.E.; Katocs, A.S. Jr.; Bloom, J.D.; Wang, C.-H.; De Vries, V.G.; Potential antiatherosclerotic agents. 5. And acyl-. J Med Chem 1986, 29, 1131.
2 De Vries, V.G. (American Cyanamid Co.); Antiatherosclerotic ureas and thioureas. BE 0900178; FR 2549473; GB 2149394; US 4623662 .
3 Castaner, J.; Prous, J.; CL-277082. Drugs Fut 1987, 12, 6, 527.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 23250 4-neopentylbenzoic acid C12H16O2 详情 详情
(II) 23251 4-neopentylbenzoyl chloride C12H15ClO 详情 详情
(III) 23252 1-heptanamine; heptylamine 111-68-2 C7H17N 详情 详情
(IV) 23253 N-heptyl-4-neopentylbenzamide C19H31NO 详情 详情
(V) 23254 N-(4-neopentylbenzyl)-1-heptanamine; N-heptyl-N-(4-neopentylbenzyl)amine C19H33N 详情 详情
(VI) 23255 2,4-difluorophenyl isocyanate; 2,4-difluoro-1-isocyanatobenzene 59025-55-7 C7H3F2NO 详情 详情
(VII) 28162 1-neopentylbenzene 1007-26-7 C11H16 详情 详情
Extended Information