3-chloro-N-(2-methoxy-4,6-dimethylphenyl)propanamide -Drug Synthesis Database

【结构式】

【分子编号】23100

【品名】3-chloro-N-(2-methoxy-4,6-dimethylphenyl)propanamide

【CA登记号】

【分子式】C₁₂H₁₆ClNO₂

【分子量】241.71728

【元素组成】C 59.63% H 6.67% Cl 14.67% N 5.79% O 13.24%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The condensation of 3-chloropropionyl chloride (I) with 2,4 dimethyl-6 methoxyaniline (II) by means of sodium acetate in glacial acetic acid gives 3-chloro-N-(2,4-dimethyl-6-methoxyphenyl)propionamide (III), which is condensed with 2-methylpiperidine (IV) in refluxing anhydrous benzene.

参考文献中间体

合成目标

【1】 Kaila, J.O.W.; Honkanen, E.J.; Alberty, J.E.; Hukki, J.J. (Orion Corporation); Novel anilides, their process of preparation and t. BE 0873957; US 4353914 .
【2】 Prous, J.; Castaner, J.; Vadocaine hydrochloride. Drugs Fut 1988, 13, 10, 936.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	18936	3-chloropropanoyl chloride	625-36-5	C₃H₄Cl₂O	详情	详情
(II)	23099	2-methoxy-4,6-dimethylphenylamine; 2-methoxy-4,6-dimethylaniline		C₉H₁₃NO	详情	详情
(III)	23100	3-chloro-N-(2-methoxy-4,6-dimethylphenyl)propanamide		C₁₂H₁₆ClNO₂	详情	详情
(IV)	23101	2-methylpiperidine	3197-42-0	C₆H₁₃N	详情	详情

Extended Information