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【结 构 式】

【分子编号】23080

【品名】1,2-bis(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methoxyethyl methyl ether; 4-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)-1,2-dimethoxyethyl]-2,2-dimethyl-1,3-dioxolane

【CA登记号】

【 分 子 式 】C14H26O6

【 分 子 量 】290.35684

【元素组成】C 57.91% H 9.03% O 33.06%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Condensation of D-mannitol (I) with acetone by means of zinc chloride gives 1,2,5,6-di-O isopropylidene-D-mannitol (II), which on treatment with dimethyl sulfate in DMSO in the presence of NaOH gives the 3,4-di-O-methyl derivative (III). Removal of the isopropylidene groups of (III) by HCl in boiling ethanol gives 3,4-di-O-methyl-o-mannitol (IV), a solution of which in pyridine is treated with methanesulfonyl chloride and subsequently with acetic anhydride to give 1,6-di-O-methylsulfonyl-2,5-di-O-acetyl-3,4-di-O-methyl-D-mannitol (V), deacetylation of which is carried out in methanol by means of hydrochloric acid.

1 Kuszmann, J.; Csanyi, E.; Kiraly, E.; GYKI-17230. Drugs Fut 1987, 12, 1, 18.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
23199 2-Propanone; Acetone; beta-ketopropane; chevron acetone;propan-2-one; Dimethyl formaldehyde; Dimethyl ketone; dimethylketal; Ketone propane; Methyl ketone; Propanone; Pyroacetic acid; Pyroacetic ether 67-64-1 C3H6O 详情 详情
(I) 23078 1,2,3,4,5,6-hexanehexol C6H14O6 详情 详情
(II) 23079 1,2-bis(2,2-dimethyl-1,3-dioxolan-4-yl)-1,2-ethanediol C12H22O6 详情 详情
(III) 23080 1,2-bis(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methoxyethyl methyl ether; 4-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)-1,2-dimethoxyethyl]-2,2-dimethyl-1,3-dioxolane C14H26O6 详情 详情
(IV) 23081 3,4-dimethoxy-1,2,5,6-hexanetetrol C8H18O6 详情 详情
(V) 23082 4-(acetoxy)-2,3-dimethoxy-5-[(methylsulfonyl)oxy]-1-[[(methylsulfonyl)oxy]methyl]pentyl acetate C14H26O12S2 详情 详情
Extended Information