N-(1-oxo-6-phenoxy-2,3-dihydro-1H-inden-5-yl)acetamide -Drug Synthesis Database

【结构式】

【分子编号】23076

【品名】N-(1-oxo-6-phenoxy-2,3-dihydro-1H-inden-5-yl)acetamide

【CA登记号】

【分子式】C₁₇H₁₅NO₃

【分子量】281.31104

【元素组成】C 72.58% H 5.37% N 4.98% O 17.06%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XII)

2) Reduction of (VII) using Raney Ni gives 5-amino-6-phenoxyindane (XI), which is acetylated with acetic anhydride and oxidized with CrO3 to yield a mixture of indanones (XII) and (XIII). Chromatographic separation and hydrolysis of (XII) with HCl in ethanol gives 5-amino-6-phenoxy-1-indanone (X), which can be mesylated, as before, to CGP-28237.

参考文献中间体

合成目标

【1】 Ferrini, P.G.; Bottcher, I.; CGP-28237. Drugs Fut 1987, 12, 1, 9.
【2】 Rufer, C.; Bahlmann, F.; Schroder, E.; Bottcher, I.; Non-steroidal antiinflammatory compounds. 8. Antii. Eur J Med Chem 1982, 17, 1, 173-80.
【3】 Schroder, E.; Lehmann, M.; Rufer, C.; Bottcher, I.; Non-steroidal antiinflammatory compounds. 6. Antii. Eur J Med Chem 1982, 17, 1, 35-42.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(VII)	23070	6-nitro-2,3-dihydro-1H-inden-5-yl phenyl ether; 5-nitro-6-phenoxyindane	C₁₅H₁₃NO₃	详情	详情
(X)	23073	5-amino-6-phenoxy-1-indanone	C₁₅H₁₃NO₂	详情	详情
(XI)	23075	6-phenoxy-2,3-dihydro-1H-inden-5-ylamine; 6-phenoxy-5-indanamine	C₁₅H₁₅NO	详情	详情
(XII)	23076	N-(1-oxo-6-phenoxy-2,3-dihydro-1H-inden-5-yl)acetamide	C₁₇H₁₅NO₃	详情	详情
(XIII)	23077	N-(3-oxo-6-phenoxy-2,3-dihydro-1H-inden-5-yl)acetamide	C₁₇H₁₅NO₃	详情	详情

Extended Information