|
【结 构 式】 
|
【分子编号】22912 【品名】4-(diisopropylamino)-2-phenyl-2-(2-pyridinyl)butanamide 【CA登记号】3737-09-5 |
【 分 子 式 】C21H29N3O 【 分 子 量 】339.48088 【元素组成】C 74.3% H 8.61% N 12.38% O 4.71% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)This compound can be obtained by two related ways: 1) The hydrogenation of 4-(diisopropylamino)-2-phenyl-2-(2-pyridyl)butyramide (I) with H2 over PtO2 in acidic water gives the corresponding piperidine derivative (II), which is acetylated with acetic anhydride to the acetylpiperidine (III). Finally, this compound is cyclized by means of KOH in DMSO. 2) The cyclization of piperidine derivative (II) whith dimethylacetamide dimethyl ketal (IV) at 80 C also yields the final produc
| 【1】 McLaughlin, K.T.; Chorvat, R.J.; Stamm, M.H.; Adelstein, G.W.; Stickney, J.L.; Rydzewski, R.M.; Prodan, K.A.; Frederick, L.G.; Schniepp, H.C.; Synthesis and structure-activity relationships of a new series of antiarrhythmic agents: 4,4-disubstituted hexahydro-3H-pyrido[1,2-c]pyrimidin-3-ones and related compounds. J Med Chem 1985, 28, 9, 1285. |
| 【2】 Adelstein, G.W.; Chorvat, R.J. (Pharmacia Corp.); Pyridopyrimidinones. EP 0104647; US 4560754 . |
| 【3】 Baxter, A.D.; Boyd, E.A.; Price, S.; Guicherit, O.M.; Porter, J.; Rubin, L.E. (Curis, Inc.); Small organic molecule regulators of cell proliferation. US 6613798; US 6683108; WO 0174344 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 22912 | 4-(diisopropylamino)-2-phenyl-2-(2-pyridinyl)butanamide | 3737-09-5 | C21H29N3O | 详情 | 详情 |
| (II) | 22913 | 4-(diisopropylamino)-2-phenyl-2-(2-piperidinyl)butanamide | C21H35N3O | 详情 | 详情 | |
| (III) | 22914 | 2-(1-acetyl-2-piperidinyl)-4-(diisopropylamino)-2-phenylbutanamide | C23H37N3O2 | 详情 | 详情 | |
| (IV) | 22915 | 1,1-dimethoxy-N,N-dimethyl-1-ethanamine;N,N-dimethylacetamide dimethylacetal; N-(1,1-dimethoxyethyl)-N,N-dimethylamine | 18871-66-4 | C6H15NO2 | 详情 | 详情 |
Extended Information