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【结 构 式】 
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【分子编号】22905 【品名】ethyl 2-[3-(4-bromo-2-fluorobenzyl)-4-oxo-3,4-dihydro-1-phthalazinyl]acetate 【CA登记号】 |
【 分 子 式 】C19H16BrFN2O3 【 分 子 量 】419.2501232 【元素组成】C 54.43% H 3.85% Br 19.06% F 4.53% N 6.68% O 11.45% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The condensation of ethyl 3,4-dihydro-4-oxo-phthalazine-1-acetate (I) with 4-bromo-2-fluoro benzyl bromide (II) by means of NaH in hot DMF gives ethyl 3-(4-bromo-2-fluorobenzyl)-3,4-dihydro-4-oxophthalazine-1-acetate (III), which is saponified with KOH in refluxing ethanol.
| 【1】 Pfaffli, P. (Novartis AG); Increasing vigilance or treating cerebral insuffi. GB 1492579; US 4146643 . |
| 【2】 Castaner, J.; Prous, J.; ICI-128436. Drugs Fut 1987, 12, 4, 347. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12095 | ethyl 2-(4-oxo-3,4-dihydro-1-phthalazinyl)acetate; Ethyl 3,4-dihydro-4-oxo-1-phthalazineacetate | 25947-13-1 | C12H12N2O3 | 详情 | 详情 |
| (II) | 22904 | 2-fluoro-4-bromobenzyl bromide; 4-bromo-1-(bromomethyl)-2-fluorobenzene | 76283-09-5 | C7H5Br2F | 详情 | 详情 |
| (III) | 22905 | ethyl 2-[3-(4-bromo-2-fluorobenzyl)-4-oxo-3,4-dihydro-1-phthalazinyl]acetate | C19H16BrFN2O3 | 详情 | 详情 |
Extended Information