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【结 构 式】 
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【分子编号】22849 【品名】5-(6-chloro-9H-purin-9-yl)-1-pentanol 【CA登记号】 |
【 分 子 式 】C10H13ClN4O 【 分 子 量 】240.69228 【元素组成】C 49.9% H 5.44% Cl 14.73% N 23.28% O 6.65% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)The reaction of 4,6-dichloropyrimidin-5-amine (I) with 5-aminopentanol (I) gives 4-chloro-6-(5-hydroxypentylamino)pyrimidin-5 amine (III), which is cyclized with triethyl orthoformate (IV) yielding 6-chloro-9-(5-hydroxypentyl)purine (V). The hydrolysis of (V) with formic acid affords 9-(5-hydroxypentyl) hypoxanthine (VI), which is treated with phosgene (VII) to give 9-[5-(chlorocarbonyloxy)pentyl]hypoxanthine (VIII). Finally, this compound is condensed with arginine (IX).
| 【1】 Stradi, R.; Cornaglia-Ferraris, P.; Perezzani, L.S.; Forni, G.; Riccardi, C.; PCF-39. Drugs Fut 1987, 12, 2, 134. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 22845 | 5-Amino-4,6-dichloropyrimidine; 4,6-dichloro-5-pyrimidinylamine; 4,6-dichloro-5-pyrimidinamine | 5413-85-4 | C4H3Cl2N3 | 详情 | 详情 |
| (II) | 22846 | 5-amino-1-pentanol | 2508-29-4 | C5H13NO | 详情 | 详情 |
| (III) | 22847 | 5-[(5-amino-6-chloro-4-pyrimidinyl)amino]-1-pentanol | C9H15ClN4O | 详情 | 详情 | |
| (IV) | 21304 | Triethyl orthoformate; 1-(Diethoxymethoxy)ethane; Diethoxymethyl ethyl ether | 122-51-0 | C7H16O3 | 详情 | 详情 |
| (V) | 22849 | 5-(6-chloro-9H-purin-9-yl)-1-pentanol | C10H13ClN4O | 详情 | 详情 | |
| (VI) | 22850 | 9-(5-hydroxypentyl)-9H-purin-6-ol | C10H14N4O2 | 详情 | 详情 | |
| (VIII) | 22852 | 9-[5-[(chlorocarbonyl)oxy]pentyl]-6-hydroxy-9H-purine | C11H13ClN4O3 | 详情 | 详情 | |
| (IX) | 22853 | Arginine; 2-Amino-5-guanidinopentanoic acid | C6H14N4O2 | 详情 | 详情 |
Extended Information