|
【结 构 式】 
|
【分子编号】22810 【品名】5-methyl-N-[4-(trifluoromethoxy)phenyl]-4-isoxazolecarboxamide 【CA登记号】 |
【 分 子 式 】C12H9F3N2O3 【 分 子 量 】286.2103496 【元素组成】C 50.36% H 3.17% F 19.91% N 9.79% O 16.77% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)Alternatively, aniline (I) was coupled with 5-methylisoxazole-4-carbonyl chloride (IV) to provide the isoxazolecarboxamide (V). The isoxazole ring was then opened with NaOH to furnish the target cyanopropenamide.
| 【1】 Ghosh, S.; Zheng, Y.; Jun, X.; Narla, R.K.; Mahajan, S.; Navara, C.; Mao, C.; Sudbeck, E.A.; Uckun, F.M.; alpha-Cyano-beta-hydroxy-beta-methyl-N-[4-(trifluoromethoxy)phenyl]propenamide: An inhibitor of the epidermal growth factor receptor tyrosine kinase with potent cytotoxic activity. Clin Cancer Res 1998, 4, 11, 2657. |
Extended Information