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【结 构 式】

【分子编号】22790

【品名】1-[(2R,4S,5R)-5-([[3,4-bis(benzyloxy)benzyl]oxy]methyl)-4-hydroxytetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione

【CA登记号】

【 分 子 式 】C31H32N2O7

【 分 子 量 】544.60436

【元素组成】C 68.37% H 5.92% N 5.14% O 20.56%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

5'-O-(3,4-dibenzyloxybenzyl)thymidine (I) was converted to the corresponding phosphoramidite (III) upon treatment with 2-cyanoethyl-N,N-diisopropylchlorophosphoramidite (II) in the presence of diisopropylethylamine. This was applied to an automatic DNA synthesizer and coupled to the polymer support-linked pentadeoxyribonucleotide sequence GGGAG (IV). The resulting oligonucleotide was liberated from the solid support using aqueous ammonia, and then purified by reverse phase-HPLC in the presence of a triethylammonium acetate buffer to furnish the title compound as the triethylammonium salt.

1 Furukawa, H.; Momota, K.; Hotoda, H.; Koizumi, M.; Kaneko, M. (Sankyo Co., Ltd.); Modified oligodeoxyribonucleotides, their preparat. EP 0611075; JP 1995053587; JP 1995087982; US 5674856; US 5807837 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 22790 1-[(2R,4S,5R)-5-([[3,4-bis(benzyloxy)benzyl]oxy]methyl)-4-hydroxytetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione C31H32N2O7 详情 详情
(II) 22791 2-Cyanoethyl N,N-diisopropylphosphoramidochloridite 89992-70-1 C9H18ClN2OP 详情 详情
(III) 22792 5-O-(3,4-Dibenzyloxybenzyl)-3-O-[2-cyanoethoxy(diisopropylamino)phosphinyl]thymidine; 5-O-(3,4-Dibenzyloxybenzyl)-3-O-[2-cyanoethoxy(diisopropylamino)phosphinyl]thymidine C40H49N4O8P 详情 详情
Extended Information