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【结 构 式】 
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【分子编号】22706 【品名】5-[4-(Ethoxycarbonyl)-3-methoxyphenyl]-2(E),4(E)-pentadienoic acid ethoxycarbonyl anhydride 【CA登记号】 |
【 分 子 式 】C18H20O7 【 分 子 量 】348.3526 【元素组成】C 62.06% H 5.79% O 32.15% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(B)TMK 688 is derived trom the condensation ot 5-(3'-methoxy-4'-hydroxyphenyl)-2,4-pentadienoic acid (IV) and N-aminoethyl 4-diphenylmethoxypiperidine (X) in the presence of ethyl chloroformate in dichloromethane. Synthesis of intermediate (IV): Vanillin (I) is protected with ethyl chloroformate to give (II), which is then treated with triethyl 4-phosphonocrotonate and followed by alkali hydrolysis to produce (IV).
| 【1】 Tasaka, K.; TMK-688. Drugs Fut 1988, 13, 12, 1056. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 22705 | ethyl (E)-4-(diethoxyphosphoryl)-2-butenoate | C10H19O5P | 详情 | 详情 | |
| (B) | 22706 | 5-[4-(Ethoxycarbonyl)-3-methoxyphenyl]-2(E),4(E)-pentadienoic acid ethoxycarbonyl anhydride | C18H20O7 | 详情 | 详情 | |
| (I) | 22701 | 4-hydroxy-3-methoxybenzaldehyde | 121-33-5 | C8H8O3 | 详情 | 详情 |
| (II) | 22702 | ethyl 4-formyl-2-methoxyphenyl carbonate | C11H12O5 | 详情 | 详情 | |
| (III) | 22703 | ethyl (2E,4E)-5-[4-[(ethoxycarbonyl)oxy]-3-methoxyphenyl]-2,4-pentadienoate | C17H20O6 | 详情 | 详情 | |
| (IV) | 22704 | (2E,4E)-5-(4-hydroxy-3-methoxyphenyl)-2,4-pentadienoic acid | C12H12O4 | 详情 | 详情 | |
| (X) | 22707 | 2-[4-(benzhydryloxy)-1-piperidinyl]ethylamine; 2-[4-(benzhydryloxy)-1-piperidinyl]-1-ethanamine | C20H26N2O | 详情 | 详情 |
Extended Information