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【结 构 式】

【分子编号】27779

【品名】1-[3-(phenylsulfanyl)propyl]piperazine

【CA登记号】

【 分 子 式 】C13H20N2S

【 分 子 量 】236.38128

【元素组成】C 66.06% H 8.53% N 11.85% S 13.57%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

The reaction of 1-bromo-3-chloropropane (I) with thiophenol (II) by means of NaOH in refluxing water gives 1-(phenylthio)-3-chloropropane (III), which is condensed with piperazine (IV) by means of NaOH in refluxing ethanol-water yielding 1-(3-phenylthiopropyl)piperazine (V). Finally, this compound is condensed with 7-(2,3-epoxypropyl)theophylline (VI) in refluxing ethanol.

1 Favier, C.; Pinhas, H.; Beranger, S.; Pascal, J.-C. (Roche Bioscience); Piperazine derivatives of theophylline. EP 0033674; GB 2069487; JP 56120683; US 4374835 .
2 Castaner, R.M.; Castaner, J.; Serradell, M.N.; Tester-Dalderup, C.; Tazifylline Hydrochloride. Drugs Fut 1987, 12, 11, 1036.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 12951 Benzenethiol; Phenylmercaptan; Phenylhydrosulfide 108-98-5 C6H6S 详情 详情
(II) 10358 1-Bromo-3-chloropropane 109-70-6 C3H6BrCl 详情 详情
(III) 27778 1-[(3-chloropropyl)sulfanyl]benzene C9H11ClS 详情 详情
(IV) 10355 Diethylenediamine; Piperazine 110-85-0 C4H10N2 详情 详情
(V) 27779 1-[3-(phenylsulfanyl)propyl]piperazine C13H20N2S 详情 详情
(VI) 27780 1,3-dimethyl-7-(2-oxiranylmethyl)-3,7-dihydro-1H-purine-2,6-dione C10H12N4O3 详情 详情
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