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【结 构 式】

【分子编号】27772

【品名】1-methyl-2-[[(methylsulfanyl)(phenylimino)methyl]imino]pyrrolidine

【CA登记号】

【 分 子 式 】C13H17N3S

【 分 子 量 】247.3642

【元素组成】C 63.12% H 6.93% N 16.99% S 12.96%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The reaction of phenyl isothiocyanate (I) with 2-imino-1-methyl pyrrolidine (II) in benzene gives N-(1-methyl-2-pyrrolidinylidene)-N'-phenylthiourea (III), which is treated with iodomethane in refluxing acetone to afford methyl N-1-methyl-2-pyrrolidinylidene)-N'-phenylcarbamidothioate (IV). Finally, this compound is treated with morpholine in refluxing isopropanol.

1 Rasmussen, C.R. (Ortho-McNeil Pharmaceutical, Inc.); Nitrogen heterocyclic carboximidamide compounds. US 4211867 .
2 Castaner, J.; Serradell, M.N.; Linogliride. Drugs Fut 1986, 11, 4, 265.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 22146 1-isothiocyanatobenzene; phenyl isothiocyanate 103-72-0 C7H5NS 详情 详情
(II) 27770 1-methyl-2-pyrrolidinimine C5H10N2 详情 详情
(III) 27771 N-(1-methyl-2-pyrrolidinylidene)-N'-phenylthiourea C12H15N3S 详情 详情
(IV) 27772 1-methyl-2-[[(methylsulfanyl)(phenylimino)methyl]imino]pyrrolidine C13H17N3S 详情 详情
(V) 10388 Morpholine 110-91-8 C4H9NO 详情 详情
Extended Information