N-methyl-N-(2-[[2-(methylamino)ethyl]disulfanyl]ethyl)-2-furamide -Drug Synthesis Database

【结构式】

【分子编号】26094

【品名】N-methyl-N-(2-[[2-(methylamino)ethyl]disulfanyl]ethyl)-2-furamide

【CA登记号】

【分子式】C₁₁H₁₈N₂O₂S₂

【分子量】274.4082

【元素组成】C 48.15% H 6.61% N 10.21% O 11.66% S 23.37%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The monoacylation of disulfide (I) with 2-furylcarbonyl chloride (II) by means of 48% HBr in ethanol/water at 80 C gives the monoamide (III), which is then condensed with 2-chloro-6,7-dimethoxyquinazoline-4-amine (IV) in refluxing isoamyl alcohol.

参考文献中间体

合成目标

【1】 Minarini, A.; Budriesi, R.; Chiarini, A.; Leonardi, A.; Melchiorre, C.; Search for alpha1-adrenoceptor subtypes selective antagonists: Design, synthesis and biological activity of cystazosin, an alpha1D-adrenoceptor antagonist. Bioorg Med Chem Lett 1998, 8, 11, 1353.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	26092	N-methyl-2-[[2-(methylamino)ethyl]disulfanyl]-1-ethanamine; N-methyl-N-(2-[[2-(methylamino)ethyl]disulfanyl]ethyl)amine		C₆H₁₆N₂S₂	详情	详情
(II)	26093	2-Furoyl chloride	527-69-5	C₅H₃ClO₂	详情	详情
(III)	26094	N-methyl-N-(2-[[2-(methylamino)ethyl]disulfanyl]ethyl)-2-furamide		C₁₁H₁₈N₂O₂S₂	详情	详情
(IV)	10143	benzyl (2S)-2-aminopropanoate		C₁₀H₁₃NO₂	详情	详情

Extended Information