合成路线1

Hydroxyacid (III) was prepared by condensation of 5-phenylpentanal (I) with the dilithium anion of propionic acid (II). Cyclization of (III) upon treatment with dipyridyl disulfide and PPh3, and then with mercuric mesylate yielded an equimolar mixture of beta-lactones (IV) and (V), from which the desired cis isomer (IV) was isolated by flash chromatography. Subsequent ring opening of (IV) with the sodium salt of 4-methoxythiophenol (VI) provided carboxylic acid (VII). This was converted to acid the corresponding chloride by means of oxalyl chloride and then condensed with O-(trimethylsilyl)hydroxylamine to produce hydroxamic acid (VIII). Finally, sulfide oxidation of (VIII) with Oxone furnished the target sulfonylhydroxamic acid.