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【结 构 式】 
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【分子编号】24195 【品名】3-bromo-2,6-dimethoxybenzoyl chloride 【CA登记号】 |
【 分 子 式 】C9H8BrClO3 【 分 子 量 】279.51742 【元素组成】C 38.67% H 2.88% Br 28.59% Cl 12.68% O 17.17% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The bromination of 2,6-dimethoxybenzoic acid (I) with Br2 in dioxane gives 3-bromo-2,6-dimethoxy benzoic acid (II), which is treated with refluxing SOCl2 yielding the corresponding acyl chloride (III). Finally, this compound is condensed with (-)-(S)-1-ethyl 2-(aminomethyl)pyrrolidine (IV).
| 【1】 Florvall, L.; Ogren, S.O.; Potential neuroleptic agents. 2,6-dialkoxybenzamide derivatives with potent dopamine receptor blocking activities. J Med Chem 1982, 25, 11, 1280. |
| 【2】 Prous, J.; Castaner, J.; Remoxipride. Drugs Fut 1986, 11, 11, 944. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 24193 | 2,6-dimethoxybenzoic acid | 1466-76-8 | C9H10O4 | 详情 | 详情 |
| (II) | 24194 | 3-bromo-2,6-dimethoxybenzoic acid | 73219-89-3 | C9H9BrO4 | 详情 | 详情 |
| (III) | 24195 | 3-bromo-2,6-dimethoxybenzoyl chloride | C9H8BrClO3 | 详情 | 详情 | |
| (IV) | 21345 | (2S)-1-Ethyl-2-(aminomethyl)pyrrolidine; [(2S)-1-Ethylpyrrolidinyl]methanamine | C7H16N2 | 详情 | 详情 |
Extended Information