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【结 构 式】 
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【分子编号】24170 【品名】N-[(E)-(3,5-dichlorophenyl)methylidene]-N-methylamine 【CA登记号】 |
【 分 子 式 】C8H7Cl2N 【 分 子 量 】188.05572 【元素组成】C 51.1% H 3.75% Cl 37.7% N 7.45% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)3,5-Dichlorobenzoic acid (I) is reduced with LiAlH4 to give 3,5-dichlorobenzyl alcohol (II). The latter is selectively oxidized with MnO2, yielding 3,5-dichlorobenzaldehyde (III). The condensation of (III) with methylamine gives the corresponding imine (IV), which can be reduced to the benzylamine (V) either with LiAlH4 or NaBH4. The hydrochloride is precipitated with etheric HCl.
| 【1】 Meindl, W.R.; et al.; Benzylamines: Synthesis and evaluation of antimycobacterial properties. J Med Chem 1984, 27, 9, 1111. |
| 【2】 Meindl, W.; Schonenberger, H.; Seydel, J.K.; Dhople, A.M.; ME-93. Drugs Fut 1987, 12, 12, 1108. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 24167 | 3,5-dichlorobenzoic acid | 51-36-5 | C7H4Cl2O2 | 详情 | 详情 |
| (II) | 24168 | (3,5-dichlorophenyl)methanol | 60211-57-6 | C7H6Cl2O | 详情 | 详情 |
| (III) | 24169 | 3,5-dichlorobenzaldehyde | 10203-08-4 | C7H4Cl2O | 详情 | 详情 |
| (IV) | 24170 | N-[(E)-(3,5-dichlorophenyl)methylidene]-N-methylamine | C8H7Cl2N | 详情 | 详情 | |
| (V) | 24171 | (3,5-dichlorophenyl)-N-methylmethanamine | C8H9Cl2N | 详情 | 详情 |
Extended Information