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【结 构 式】

【分子编号】22618

【品名】3-bromopropanoyl bromide

【CA登记号】

【 分 子 式 】C3H4Br2O

【 分 子 量 】215.87216

【元素组成】C 16.69% H 1.87% Br 74.03% O 7.41%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

The acylation of 2,3,4,5-tetrahydrobenzo-1,5 thiazepine (I) with 3-bromopropionyl bromide (II) by means of pyridine in toluene gives 5-(3-bromo-propionyl)-2,3,4,5 tetrahydrobenzo-1,5-thiazepine (III), which is then condensed with 2-(3,4-dimethoxyphenyl)ethylamine (IV) in refluxing dichloromethane, and treated with fumaric acid.

1 Tomiyama, T. (Kotobuki Pharmaceutical Co., Ltd.); Antihypertensive 1,5-benzothiazepine derivs. and compsns. thereof. US 4584292 .
2 Prous, J.; Castaner, J.; KT-362. Drugs Fut 1988, 13, 7, 622.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 22617 2,3,4,5-tetrahydro-1,5-benzothiazepine C9H11NS 详情 详情
(II) 22618 3-bromopropanoyl bromide C3H4Br2O 详情 详情
(III) 22619 3-bromo-1-[3,4-dihydro-1,5-benzothiazepin-5(2H)-yl]-1-propanone C12H14BrNOS 详情 详情
(IV) 10098 2-(3,4-Dimethoxyphenyl)-1-ethanamine; 3,4-Dimethoxyphenethylamine; 2-(3,4-Dimethoxyphenyl)ethylamine 120-20-7 C10H15NO2 详情 详情
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