2-(1-ethylpropyl)-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one -Drug Synthesis Database

【结构式】

【分子编号】22485

【品名】2-(1-ethylpropyl)-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

【CA登记号】

【分子式】C₂₃H₂₉N₅O₂

【分子量】407.51576

【元素组成】C 67.79% H 7.17% N 17.19% O 7.85%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The synthesis of [3H]-SCH-51048 has been described:The tritiation of phenol (I) with tritiated heptafluorobutyric acid at 115 C gives the polytritiated intermediate (II), which is then condensed with the chiral tosylate (III) by means of NaOH in DMSO affording labeled SCH-51048.

参考文献中间体

合成目标

【1】 Magatti, C.V.; et al.; Synthesis of H-3-SCH 51048 and C-14-SCH 56592. J Label Compd Radiopharm 1998, 41, 8, 731.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	16310	2-(1-ethylpropyl)-4-[4-[4-(4-hydroxyphenyl)piperazino]phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one	C₂₃H₂₉N₅O₂	详情	详情
(II)	22485	2-(1-ethylpropyl)-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one	C₂₃H₂₉N₅O₂	详情	详情
(II)	45295	2-(1-ethylpropyl)-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one	C₂₃H₂₉N₅O₂	详情	详情
(III)	16311	[(3S,5R)-5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-ylmethyl)tetrahydro-3-furanyl]methyl 4-methylbenzenesulfonate	C₂₁H₂₁F₂N₃O₄S	详情	详情

Extended Information