【结 构 式】 |
【分子编号】22427 【品名】5-[[(1S)-1,2-dimethyl-2-propenyl]oxy]-2,2-dimethyl-10-propyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-8-one 【CA登记号】 |
【 分 子 式 】C22H28O4 【 分 子 量 】356.46192 【元素组成】C 74.13% H 7.92% O 17.95% |
合成路线1
该中间体在本合成路线中的序号:(XXVI)3) Synthesis of ent-Calanolide A, (-)-calanolide A: The Clemensen reduction of 5,7-dihydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-one (XXI) with Zn/HCl in methanol gives 5,7-dihydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran (XXII), which is condensed with methyl 2-hexynoate (XXIII) using the palladium catalyst Pd2dba3 to yield dihydrobenzodipyran (XXIV). The regio- and enantioselective allylic alkylation of (XXIV) with 2-methyl-2(E)-butenyl carbonate (XXV) catalyzed by Pd2dba3 using a chiral ligand affords the chiral dihydrobenzodipyran ether (XXVI), which is dehydrogenated with dichlorodicyanobenzoquinone (DDQ) in dioxane to (XXVII). The chemoselective hydroboration of (XXVII) with 9-BBN and H2O2 gives the alcohol (XXVIII) with high diastereomeric selectivity. The Dess-Martin oxidation of (XXVIII) yields the expected aldehyde (XXIX), which is cyclized to (10S,11R,12R)-benzotripyran (XXX) (ent-calanolide B). Finally, this compound is converted into ent-calanolide A by inversion of the C-12 hydroxy group carried out with a modified Mitsunobu reaction with dimethyl azodicarboxylate (DEAD)/trimethylphosphine/chloroacetic acid in toluene/THF, followed by treatment with NH4OH in methanol. The authors indicate that Calanolide A can be synthesized in the same way by simply using the mirror image of the chiral ligand in the addition of carbonate (XXV) to dihydrobenzodipyran (XXIV).
【1】 Castañer, J.; Leeson, P.; Sorbera, L.A.; Calanolide A. Drugs Fut 1999, 24, 3, 235. |
【2】 Toste, F.D.; Trost, B.M.; A catalytic enantioselective approach to chromans. J Am Chem Soc 1998, 120, 35, 9074. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(XXI) | 22422 | 5,7-dihydroxy-2,2-dimethyl-2,3-dihydro-4H-chromen-4-one | C11H12O4 | 详情 | 详情 | |
(XXII) | 22423 | 2,2-dimethyl-5,7-chromanediol | C11H14O3 | 详情 | 详情 | |
(XXIII) | 19609 | methyl 2-hexynoate | 18937-79-6 | C7H10O2 | 详情 | 详情 |
(XXIV) | 22425 | 5-hydroxy-2,2-dimethyl-10-propyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-8-one | C17H20O4 | 详情 | 详情 | |
(XXV) | 22426 | methyl (E)-2-methyl-2-butenyl carbonate | C7H12O3 | 详情 | 详情 | |
(XXVI) | 22427 | 5-[[(1S)-1,2-dimethyl-2-propenyl]oxy]-2,2-dimethyl-10-propyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-8-one | C22H28O4 | 详情 | 详情 | |
(XXVII) | 22428 | 5-[[(1S)-1,2-dimethyl-2-propenyl]oxy]-2,2-dimethyl-10-propyl-2H,8H-pyrano[2,3-f]chromen-8-one | C22H26O4 | 详情 | 详情 | |
(XXVIII) | 22429 | 5-[[(1S,2R)-3-hydroxy-1,2-dimethylpropyl]oxy]-2,2-dimethyl-10-propyl-2H,8H-pyrano[2,3-f]chromen-8-one | C22H28O5 | 详情 | 详情 | |
(XXIX) | 22430 | (2S,3S)-3-[(2,2-dimethyl-8-oxo-10-propyl-2H,8H-pyrano[2,3-f]chromen-5-yl)oxy]-2-methylbutanal | C22H26O5 | 详情 | 详情 | |
(XXX) | 22431 | (10S,11R,12S)-12-hydroxy-6,6,10,11-tetramethyl-4-propyl-11,12-dihydro-2H,6H,10H-dipyrano[2,3-f:2,3-h]chromen-2-one | C22H26O5 | 详情 | 详情 |