3-(4-fluorophenyl)-5-hydroxy-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone -Drug Synthesis Database

【结构式】

【分子编号】22275

【品名】3-(4-fluorophenyl)-5-hydroxy-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone

【CA登记号】

【分子式】C₁₇H₁₃FO₅S

【分子量】348.3516232

【元素组成】C 58.62% H 3.76% F 5.45% O 22.96% S 9.21%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

Cyclization of hydroxyfuranone (I) with hydrazine in refluxing EtOH produced the pyridazinone (II), which was subsequently alkylated with cyclopropylmethyl bromide (III) in the presence of NaOH to afford the title compound.

参考文献中间体

合成目标

【1】 Therien, M.; Li, C.S.; Lau, C.K.; Prasit, P.; Gauthier, J.Y. (Merck Frosst Canada Inc.); Pyridazinones as inhibitors of cyclooxygenase-2. EP 0975604; US 6004960; WO 9841511 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	22275	3-(4-fluorophenyl)-5-hydroxy-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone		C₁₇H₁₃FO₅S	详情	详情
(II)	22276	4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone		C₁₇H₁₃FN₂O₃S	详情	详情
(III)	22277	Cyclopropyl bromide; 1-(Bromomethyl)cyclopropane	7051-34-5	C₄H₇Br	详情	详情

Extended Information