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【结 构 式】 
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【分子编号】22227 【品名】(2S)-2-[(2R)-8-(2,4-dichlorophenyl)-2-hydroxyoctyl]-2-hydroxybutanedioic acid 【CA登记号】 |
【 分 子 式 】C18H24Cl2O6 【 分 子 量 】407.29036 【元素组成】C 53.08% H 5.94% Cl 17.41% O 23.57% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(rac-XVII)2) Alternatively, aldehyde (VII) was condensed with the dianion of methyl acetoacetate (XIV) to give hydroxyketone (XV), which was converted to the cyanohydrin (XVI) using KCN and KH2PO4. Basic hydrolysis of (XV) then provided a mixture of the (3R*,5S*)- (XIII) and (3R*,5R*)- (XVII) diastereoisomers.
| 【1】 Gribble, A.D.; Ife, R.J.; Shaw, A.; McNair, D.; Novelli, C.E.; Bakewell, S.; Shah, V.P.; Dolle, R.E.; Groot, P.H.; Pearce, N.; Yates, J.; Tew, D.; Boyd, H.; Ashman, S.; Eggleston, D.S.; Haltiwanger, R.C.; Okafo, G.; ATP-citrate lyase as a target for hypolipidemic intervention. 2. Synthesis and evaluation of (3R*,5S*)-omega-substituted-3-carboxy-3,5-dihydroxyalkanoic acids and their gamma-lactone prodrugs as inhibitors of the enzyme in vitro and in vivo. J Med Chem 1998, 41, 19, 3582. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (rac-XIII) | 22208 | 2-[8-(2,4-Dichlorophenyl)-2(R)-hydroxyoctyl]-2-hydroxysuccinic acid disodium salt | C20H28Cl2O4 | 详情 | 详情 | |
| (rac-XVII) | 22227 | (2S)-2-[(2R)-8-(2,4-dichlorophenyl)-2-hydroxyoctyl]-2-hydroxybutanedioic acid | C18H24Cl2O6 | 详情 | 详情 | |
| (VII) | 22202 | 7-(2,4-dichlorophenyl)heptanal | C13H16Cl2O | 详情 | 详情 | |
| (XIV) | 11791 | methyl 3-oxobutanoate; Methyl acetoacetate | 105-45-3 | C5H8O3 | 详情 | 详情 |
| (XV) | 22225 | methyl 11-(2,4-dichlorophenyl)-5-hydroxy-3-oxoundecanoate | C18H24Cl2O4 | 详情 | 详情 | |
| (XVI) | 22226 | methyl 3-cyano-11-(2,4-dichlorophenyl)-3,5-dihydroxyundecanoate | C19H25Cl2NO4 | 详情 | 详情 |
Extended Information