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【结 构 式】 
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【分子编号】22156 【品名】N-[(E)-1-(methylsulfanyl)-2-nitroethenyl]cyclohexanamine; N-cyclohexyl-N-[(E)-1-(methylsulfanyl)-2-nitroethenyl]amine 【CA登记号】 |
【 分 子 式 】C9H16N2O2S 【 分 子 量 】216.30432 【元素组成】C 49.98% H 7.46% N 12.95% O 14.79% S 14.82% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VI)Condensation of chloropyridine (I) with cyclooctylamine (II) provided the cyclooctylaminopyridine (III). The aminonitroethylene derivative (VI) was prepared by reaction of 1,1-bis(methylsulfanyl)-2-nitroethylene (IV) with cyclohexylamine (V) in refluxing EtOH. Subsequent condensation of this intermediate with the sodium salt of sulfonamide (III) yielded the title compound.
| 【1】 Masereel, B.; Wouters, J.; Pochet, L.; Lambert, D.; Design, synthesis, and anticonvulsant activity of 1-(pyrid-3-ylsulfonamido)-2-nitroethylenes. J Med Chem 1998, 41, 17, 3239. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 22151 | 4-chloro-3-pyridinesulfonamide | C5H5ClN2O2S | 详情 | 详情 | |
| (II) | 17996 | 3-(1H-pyrazol-5-yl)benzaldehyde | C10H8N2O | 详情 | 详情 | |
| (II) | 22152 | cyclooctanamine; cyclooctylamine | 5452-37-9 | C8H17N | 详情 | 详情 |
| (III) | 22153 | 4-(cyclooctylamino)-3-pyridinesulfonamide | C13H21N3O2S | 详情 | 详情 | |
| (VI) | 13853 | Methyl 1-(methylsulfanyl)-2-nitrovinyl sulfide; 1,1-Bis(methylthio)-2-nitroethylene; 1,1-Bis(methylsulfanyl)-2-nitroethylene | 13623-94-4 | C4H7NO2S2 | 详情 | 详情 |
| (VI) | 22156 | N-[(E)-1-(methylsulfanyl)-2-nitroethenyl]cyclohexanamine; N-cyclohexyl-N-[(E)-1-(methylsulfanyl)-2-nitroethenyl]amine | C9H16N2O2S | 详情 | 详情 |
Extended Information