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【结 构 式】

【分子编号】21830

【品名】(7aR)-1-((1R,4S)-4-[[tert-butyl(dimethyl)silyl]oxy]-1,5-dimethyl-5-nitrohexyl)-7a-methyloctahydro-4H-inden-4-one

【CA登记号】

【 分 子 式 】C24H45NO4Si

【 分 子 量 】439.71114

【元素组成】C 65.56% H 10.32% N 3.19% O 14.55% Si 6.39%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VI)

Condensation of aldehyde (I) with 2-nitropropane (II) using tert-butyldimethylsilyl chloride, tetrabutylammonium fluoride and triethylamine afforded a mixture of diastereomeric nitroaldol products (III). After separation by column chromatography, the desired isomer was protected as the tert-butyldimethylsilyl ether (IV). Deprotection of the benzoate ester of (IV) was carried out by reduction with diisobutylaluminum hydride to provide alcohol (V), which was then oxidized to the corresponding ketone (VI) with pyridinium chlorochromate. Wittig reaction of (VI) with phosphorane (VII) provided the bromomethylene compound (VIII).

1 Oshida, J.; et al.; Synthesis and biological evaluation of 1alpha,24-dihydroxy-25-nitrovitamin D3. Bioorg Med Chem Lett 1999, 9, 3, 381.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 21818 (4S,7aR)-7a-methyl-1-[(1R)-1-methyl-4-oxobutyl]octahydro-1H-inden-4-yl benzoate C22H30O3 详情 详情
(II) 21819 2-nitropropane 79-46-9 C3H7NO2 详情 详情
(III) 21820 (4S,7aR)-1-[(1R)-4-hydroxy-1,5-dimethyl-5-nitrohexyl]-7a-methyloctahydro-1H-inden-4-yl benzoate C25H37NO5 详情 详情
(IV) 21828 (4S,7aR)-1-((1R,4S)-4-[[tert-butyl(dimethyl)silyl]oxy]-1,5-dimethyl-5-nitrohexyl)-7a-methyloctahydro-1H-inden-4-yl benzoate C31H51NO5Si 详情 详情
(V) 21829 (4S,7aR)-1-((1R,4S)-4-[[tert-butyl(dimethyl)silyl]oxy]-1,5-dimethyl-5-nitrohexyl)-7a-methyloctahydro-1H-inden-4-ol C24H47NO4Si 详情 详情
(VI) 21830 (7aR)-1-((1R,4S)-4-[[tert-butyl(dimethyl)silyl]oxy]-1,5-dimethyl-5-nitrohexyl)-7a-methyloctahydro-4H-inden-4-one C24H45NO4Si 详情 详情
(VII) 21831 (bromomethyl)(triphenyl)phosphonium bromide 1034-49-7 C19H17Br2P 详情 详情
(VIII) 21832 (1S,4R)-4-[(7aR)-4-[(E)-bromomethylidene]-7a-methyloctahydro-1H-inden-1-yl]-1-(1-methyl-1-nitroethyl)pentyl tert-butyl(dimethyl)silyl ether; [[(1S,4R)-4-[(7aR)-4-[(E)-bromomethylidene]-7a-methyloctahydro-1H-inden-1-yl]-1-(1-methyl-1-nitroethyl)pentyl]oxy](tert-butyl)dimethylsilane C25H46BrNO3Si 详情 详情
Extended Information