• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】21825

【品名】(1R,4R)-4-[(7aR)-4-[(E)-bromomethylidene]-7a-methyloctahydro-1H-inden-1-yl]-1-(1-methyl-1-nitroethyl)pentyl trimethylsilyl ether; [[(1R,4R)-4-[(7aR)-4-[(E)-bromomethylidene]-7a-methyloctahydro-1H-inden-1-yl]-1-(1-methyl-1-nitroethyl)pentyl]oxy](trimethyl)silane

【CA登记号】

【 分 子 式 】C22H40BrNO3Si

【 分 子 量 】474.55404

【元素组成】C 55.68% H 8.5% Br 16.84% N 2.95% O 10.11% Si 5.92%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IX)

Further exchange of the protecting group of (VIII) from tert-butyldimethylsilyl to trimethylsilyl ether (IX) was carried out by desilylation with LiBF4 and H2SO4, followed by treatment with (trimethylsilyl)imidazole. The resulting compound (IX) was cyclized with enyne (X) using Pd2(dba)3, Et3N and PPh3 to afford triene (XI), which was finally desilylated with pyridinium tosylate.

1 Oshida, J.; et al.; Synthesis and biological evaluation of 1alpha,24-dihydroxy-25-nitrovitamin D3. Bioorg Med Chem Lett 1999, 9, 3, 381.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(VIII) 21824 [[(1R,4R)-4-[(7aR)-4-[(E)-bromomethylidene]-7a-methyloctahydro-1H-inden-1-yl]-1-(1-methyl-1-nitroethyl)pentyl]oxy](tert-butyl)dimethylsilane; (1R,4R)-4-[(7aR)-4-[(E)-bromomethylidene]-7a-methyloctahydro-1H-inden-1-yl]-1-(1-methyl-1-nitroethyl)pentyl tert-butyl(dimethyl)silyl ether C25H46BrNO3Si 详情 详情
(IX) 21825 (1R,4R)-4-[(7aR)-4-[(E)-bromomethylidene]-7a-methyloctahydro-1H-inden-1-yl]-1-(1-methyl-1-nitroethyl)pentyl trimethylsilyl ether; [[(1R,4R)-4-[(7aR)-4-[(E)-bromomethylidene]-7a-methyloctahydro-1H-inden-1-yl]-1-(1-methyl-1-nitroethyl)pentyl]oxy](trimethyl)silane C22H40BrNO3Si 详情 详情
(X) 21826 (5R,7S)-3,3,9,9-tetraethyl-5-(2-propynyl)-7-vinyl-4,8-dioxa-3,9-disilaundecane; (1R,3S)-1-(2-propynyl)-3-[(triethylsilyl)oxy]-4-pentenyl triethylsilyl ether C20H40O2Si2 详情 详情
(XI) 21827 [[(1R,4R)-4-[(7aR)-7a-methyl-4-((E)-2-[(3S,5R)-2-methylene-3,5-bis[(triethylsilyl)oxy]cyclohexylidene]ethylidene)octahydro-1H-inden-1-yl]-1-(1-methyl-1-nitroethyl)pentyl]oxy](trimethyl)silane; (1R,4R)-4-[(7aR)-7a-methyl-4-((E)-2-[(3S,5R)-2-methylene-3,5-bis[(triethylsilyl)oxy]cyclohexylidene]ethylidene)octahydro-1H-inden-1-yl]-1-(1-methyl-1-nitroethyl)pentyl trimethylsilyl ether C42H79NO5Si3 详情 详情
Extended Information