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【结 构 式】 
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【分子编号】21634 【品名】(7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-([[(1S)-1-carboxyethyl]oxy]imino)acetyl]amino]-3-[[(5-methyl[1,3]thiazolo[4,5-c]pyridin-5-ium-2-yl)sulfanyl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 【CA登记号】 |
【 分 子 式 】C23H21N7O7S4 【 分 子 量 】635.72672 【元素组成】C 43.45% H 3.33% N 15.42% O 17.62% S 20.18% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VIII)Pyridinium salt (VII) was followed by deprotection of the N-trityl and the benzyl ester groups in trifluoroacetic acid containing anisole, to furnish acid (VIII) as the inner salt with the pyridinium group. The remaining carboxylic acid group of (VIII) was finally converted to the sodium salt upon treatment with aqueous NaHCO3, and the target compound was purified by Diaion HP-20 column chromatography.
| 【1】 Tsushima, M.; Kano, Y.; Iwamatsu, K.; Tamura, A.; Umemura, E.; Shibahara, S.; Novel cephalosporin derivatives possessing a bicyclic heterocycle at the 3-position. Part II: Synthesis and antibacterial activity of 3-(5-methylthiazolo[4,5-c]pyridinium-2-yl)thiomethylcephalosporin derivatives and related compounds. Bioorg Med Chem 1998, 6, 9, 1641. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VII) | 21632 | 2-[[((7R)-7-([2-([[(1S)-2-(benzhydryloxy)-1-methyl-2-oxoethyl]oxy]imino)-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino)-2-[[(4-methoxybenzyl)oxy]carbonyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl]sulfanyl]-5-methyl[1,3]thiazolo[4,5-c]pyridin-5-ium iodide | C63H54IN7O8S4 | 详情 | 详情 | |
| (VIII) | 21634 | (7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-([[(1S)-1-carboxyethyl]oxy]imino)acetyl]amino]-3-[[(5-methyl[1,3]thiazolo[4,5-c]pyridin-5-ium-2-yl)sulfanyl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | C23H21N7O7S4 | 详情 | 详情 |
Extended Information