【结 构 式】 |
【分子编号】21599 【品名】3,3-dimethyl-1,3-dihydro-2H-indol-2-one 【CA登记号】 |
【 分 子 式 】C10H11NO 【 分 子 量 】161.20348 【元素组成】C 74.51% H 6.88% N 8.69% O 9.92% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(II)Rearrangement of 2-methylpropanoic acid, 2-phenylhydrazide (I) provides 1,3-dihydro-3,3-dimethyl-2H-indol-2-one (II). Friedel Crafts' acylation of (II) with succinic anhydride in an aluminum chloride/DMF melt results in the formation of 4-oxobutanoic acid (III). Cyclization of (III) with hydrazine in refluxing ethanol completes the preparation of LY-195115.
【1】 Hayes, J.S.; Robertson, D.W.; LY-195115 . Drugs Fut 1986, 11, 5, 377. |
【2】 Robertson, D.W.; et al.; Dihydropyridazinone cardiotonics: The discovery and inotropic activity of 1,3-dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H-indol-2-one. J Med Chem 1986, 29, 10, 1832-40. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(A) | 11291 | Dihydro-2,5-furandione; Succinic anhydride | 108-30-5 | C4H4O3 | 详情 | 详情 |
(I) | 24021 | 2-methyl-N'-phenylpropanohydrazide | C10H14N2O | 详情 | 详情 | |
(II) | 21599 | 3,3-dimethyl-1,3-dihydro-2H-indol-2-one | C10H11NO | 详情 | 详情 | |
(III) | 24024 | 4-(3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-4-oxobutyric acid | C14H15NO4 | 详情 | 详情 |
Extended Information