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【结 构 式】 
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【分子编号】21561 【品名】1-chloro-1-[[(chlorooxy)carbonyl]oxy]ethane 【CA登记号】 |
【 分 子 式 】C3H4Cl2O3 【 分 子 量 】158.96836 【元素组成】C 22.67% H 2.54% Cl 44.6% O 30.19% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VIII)3) The iodoester (III) is obtained as follows: The chlorination of ethyl chloroformate (VII) with SO2Cl2 and benzoyl peroxide gives 1-chloroethyl-chloroformate (VIII), which is esterified with o-propanol in pyridine to afford 1-chloroethyl isopropyl carbonate (IX). Finally, this compound is iodinated with NaI and 18-crown-6 in refluxing benzene.
| 【1】 Fujimoto, K.; Nakayama, E.; Nakao, H. (Sankyo Co., Ltd.); Process for preparing 3-alkoxymethylcephalosporin derivatives. DE 3244457 . |
| 【2】 Castaner, J.; Serradell, M.N.; Cefpodoxime Proxetil. Drugs Fut 1988, 13, 1, 16. |
| 【3】 Fujimoto, K.; Ishihara, S.; Yanagisawa, H.; Ide, J.; Nakayama, E.; Nakao, H.; Sugawara, S.; Iwata, M.; Studies on orally active cephalosporin esters. J Antibiot 1987, 40, 3, 370. |
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