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【结 构 式】 
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【分子编号】21453 【品名】7-methyl-2H-chromen-2-one 【CA登记号】2445-83-2 |
【 分 子 式 】C10H8O2 【 分 子 量 】160.17232 【元素组成】C 74.99% H 5.03% O 19.98% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)Photochemical bromination of 7-methylcoumarin (I) using N-bromosuccinimide and azobis(isobutyronitrile) provided the benzylic bromide (II). N-Phenyl ethylenediamine (V) was prepared by reaction between aniline (III) and oxazolidone (IV) at 140 C. Then, alkylation of amine (V) with bromide (II) in the presence of K2CO3 in refluxing acetonitrile provided the title compound.
| 【1】 Kesten, S.R.; et al.; Design, synthesis, and evaluation of coumarins as potent and selective dopamine D4 antagonists. 216th ACS Natl Meet (Aug. 23-27, Boston) 1998, Abst MEDI 123. |
| 【2】 Johnson, S.J.; Heffner, T.G.; Kesten, S.R.; Wise, L.D.; Wright, J.L.; Pugsley, T.A.; Design, synthesis, and evaluation of chromen-2-ones as potent and selective human dopamine D4 antagonists. J Med Chem 1999, 42, 18, 3718. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 21453 | 7-methyl-2H-chromen-2-one | 2445-83-2 | C10H8O2 | 详情 | 详情 |
| (II) | 21454 | 7-(bromomethyl)-2H-chromen-2-one | C10H7BrO2 | 详情 | 详情 | |
| (III) | 12294 | Aniline; Phenylamine | 62-53-3 | C6H7N | 详情 | 详情 |
| (IV) | 21456 | 1,3-oxazolidin-2-one | 497-25-6 | C3H5NO2 | 详情 | 详情 |
| (V) | 21457 | N(1)-phenyl-1,2-ethanediamine; N-(2-aminoethyl)-N-phenylamine | 1664-40-0 | C8H12N2 | 详情 | 详情 |
Extended Information