(1R,9S,10R)-10-(hydroxymethyl)-4-methyl-8,11-dioxa-2,6-diazatricyclo[7.2.1.0(2,7)]dodeca-3,6-dien-5-one; 2,3'-Anhydrothymidine; 2,3'-2,3'-Anhydrothimidine -Drug Synthesis Database

【结构式】

【分子编号】24471

【品名】(1R,9S,10R)-10-(hydroxymethyl)-4-methyl-8,11-dioxa-2,6-diazatricyclo[7.2.1.0(2,7)]dodeca-3,6-dien-5-one; 2,3'-Anhydrothymidine; 2,3'-2,3'-Anhydrothimidine

【CA登记号】

【分子式】C₁₀H₁₂N₂O₄

【分子量】224.21636

【元素组成】C 53.57% H 5.39% N 12.49% O 28.54%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VII)

2) The anhydrization of thymidine (VI) with 2-chloro-1,2-difluorotriethylamine in hot DMF gives 2,3'-anhydrothymidine (VII), which is then treated with lithium azide and NH4Cl in hot DMF.

参考文献中间体

合成目标

【1】 Glinski, R.P.; et al.; Nucleotide synthesis. IV. Phosphorylated 3'-amino-3'-deoxythymidine and 5'-amino-5'-deoxythymidine and derivatives. J Org Chem 1973, 38, 25, 4299.
【2】 Castaner, J.; Prous, J.; BW-A 509 U. Drugs Fut 1986, 11, 12, 1017.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(VI)	12161	Thymidine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione	50-89-5	C₁₀H₁₄N₂O₅	详情	详情
(VII)	24471	(1R,9S,10R)-10-(hydroxymethyl)-4-methyl-8,11-dioxa-2,6-diazatricyclo[7.2.1.0(2,7)]dodeca-3,6-dien-5-one; 2,3'-Anhydrothymidine; 2,3'-2,3'-Anhydrothimidine		C₁₀H₁₂N₂O₄	详情	详情

Extended Information