【结 构 式】 |
【分子编号】24452 【品名】1-(2-oxiranylmethyl)piperidine 【CA登记号】 |
【 分 子 式 】C8H15NO 【 分 子 量 】141.21324 【元素组成】C 68.04% H 10.71% N 9.92% O 11.33% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号:(II)1) By condensation of 2-nitroimidazole (I) with 3-(1-piperidino)propyliene oxide (II) in refluxing ethanol.
【1】 Grimmelikhuysen, J.; Schroeder, A. (Unilever NV); Preparation of polyacetylalkylenediamines. BE 769655; DE 2133458; FR 2100320; GB 1335204 . |
【2】 Castaner, J.; Prous, J.; RO-038799. Drugs Fut 1986, 11, 7, 580. |
合成路线2
该中间体在本合成路线中的序号:(III)N-(2,3-Epoxypropyl)piperidine (III), prepared from piperidine (I) and epichlorhydrin (II), was condensed with nicotinic acid amidoxime (IV) in the presence of basic catalysts, such as NaOH, t-BuOK, Al2O3 or SnO2, in hot DMF to provide the title compound, which was finally converted to the dihydrochloride salt.
【1】 Somfai, E,; Bertok, B.; Szekely, I.; Takacs, K.; Thurner, A.; Gajary, A.; Botar, S.; Nagy, L. (Chinoin Pharmaceutical and Chemical Works Co., Ltd.); Improved process for the preparation of amidoxime derivs.. WO 9008131 . |
Extended Information