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【结 构 式】 
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【分子编号】28215 【品名】5-imino-4,4-dimethyl-1-[4-nitro-3-(trifluoromethyl)phenyl]-2-imidazolidinone 【CA登记号】 |
【 分 子 式 】C12H11F3N4O3 【 分 子 量 】316.2397096 【元素组成】C 45.58% H 3.51% F 18.02% N 17.72% O 15.18% |
合成路线1
该中间体在本合成路线中的序号：(III)3-Trifluoromethyl-4-nitrophenylisocyanate (I) and 2-amino-2-cyanopropane (II) are condensed. After concentration by distillation under reduced pressure and chromatography of the residue on silica gel (elution with dichloromethane: acetone, 8:2 v/v), the intermediate 1-(3'-trifluoromethyl-4'-nitrophenyl)-4,4-dimethyl-5-imino-2-imidazolidinone) (III) is obtained. This intermediate, in suspension in aqueous hydrochloric acid, is heated, then cooled and poured into water. The precipitate, filtered, washed and dried, is anandron (RU-23908), which can be recrystallized in an ethanolic medium.
| 【1】 Perronet, J.; Girault, P.; Bonne, C. (Aventis Pharma SA); 1-(3-(4-O-Trifluoromethyl-4-(4-O-nitrophenyl)-4,4-dimethyl)imidazolidines. DE 2649925; ES 452746; FR 2329276; FR 7533084; GB 1518444; JP 52057176; US 4097578 . |
| 【2】 Ojasoo, T.; Nilutamide. Drugs Fut 1987, 12, 8, 763. |