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【结 构 式】 
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【分子编号】21096 【品名】5-[(E)-2-bromoethenyl]-2,4-bis[(trimethylsilyl)methyl]pyrimidine 【CA登记号】 |
【 分 子 式 】C14H25BrN2Si2 【 分 子 量 】357.44098 【元素组成】C 47.04% H 7.05% Br 22.35% N 7.84% Si 15.71% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The condensation of 2-deoxy-3,5-di-O-(phenylacetyl)-beta-D-erythro-pentofuranosyl chloride (I) with 2,4-bis-O-(trimethylsilyl)-5(E)-(2-bromovinyl)uracil (II) in acetonitrile (Lewis acid catalyst), or in CHCl3-pyridine (Bronsted acid catalyst), gives 3',5'-di-O-(phenylacetyl)-5(E)-(2-bromovinyl)-2'-deoxyuridine (III) and its anomer that is eliminated by TLC (silicagel). Finally, (III) is treated with sodium methoxide in methanol.
| 【1】 Kulikowski, T.; Felczak, K.; Poznanski, J.; Remin, M.; Novel syntheses and solution conformations of (E)-5-(2-bromovinyl)-2'-deoxyuridine. Int Symp: Basic Clin Approach Virus Chemother 1988, Poster M17. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 21095 | 5-chloro-2-[[(2-phenylacetyl)oxy]methyl]tetrahydro-3-furanyl 2-phenylacetate | C21H21ClO5 | 详情 | 详情 | |
| (II) | 21096 | 5-[(E)-2-bromoethenyl]-2,4-bis[(trimethylsilyl)methyl]pyrimidine | C14H25BrN2Si2 | 详情 | 详情 | |
| (III) | 21097 | 5-[5-[(E)-2-bromoethenyl]-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]-2-[[(2-phenylacetyl)oxy]methyl]tetrahydro-3-furanyl 2-phenylacetate | C27H25BrN2O7 | 详情 | 详情 |
Extended Information