|
【结 构 式】 
|
【分子编号】21029 【品名】7,8-dihydropyrido[1,2-a]benzimidazol-9(6H)-one 【CA登记号】 |
【 分 子 式 】C11H10N2O 【 分 子 量 】186.21328 【元素组成】C 70.95% H 5.41% N 15.04% O 8.59% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)1,3-Cyclohexanedione (I) was brominated in cold water, and the resulting 2-bromo-1,3-cyclohexanedione (II) was condensed with 2-aminopyridine (III) in boiling EtOH to afford the dihydropyridobenzimidazolone (IV). Further bromination in concentrated HBr at 70 C gave bromoketone (V), which was finally condensed with thiourea (VI) in EtOH to yield the target tetracyclic compound.
| 【1】 Yoo, H.Y.; Chung, K.J.; Chai, J.P.; Chang, M.S.; Kim, S.G.; Choi, W.S.; Kim, Y.H.; Chun, J.K.; Chung, Y.K.; Kim, Y.H.; Paek, J.H.; Seo, K.H.; Kang, D.P. (Yung-Jin Pharmaceutical Co., Ltd.); Heterocycle-fused thiazole derivs.. EP 0843681; JP 1998508877; WO 9703076 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11244 | 1,3-Cyclohexanedione | 504-02-9 | C6H8O2 | 详情 | 详情 |
| (II) | 21027 | 2-bromo-1,3-cyclohexanedione | C6H7BrO2 | 详情 | 详情 | |
| (III) | 11305 | 2-Pyridinamine; 2-Pyridinylamine; 2-Aminopyridine | 504-29-0 | C5H6N2 | 详情 | 详情 |
| (IV) | 10180 | Thiourea | 62-56-6 | CH4N2S | 详情 | 详情 |
| (IV) | 21029 | 7,8-dihydropyrido[1,2-a]benzimidazol-9(6H)-one | C11H10N2O | 详情 | 详情 | |
| (V) | 21030 | 8-bromo-7,8-dihydropyrido[1,2-a]benzimidazol-9(6H)-one | C11H9BrN2O | 详情 | 详情 |
Extended Information