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【结 构 式】 
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【分子编号】20938 【品名】3-pyrrolidinamine; 3-pyrrolidinylamine 【CA登记号】 |
【 分 子 式 】C4H10N2 【 分 子 量 】86.13688 【元素组成】C 55.78% H 11.7% N 32.52% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate (I) is reacted with 3-aminopyrrolidine dihydrochloride (II), and then the resulting mixture is reacted with potassium hydroxide and p-toluenesulfonic acid monohydrate in order to obtain (rac)-7-(3-amino-1-pyrrolidinyl)-6-fluoro-1-(2,4-difluorophenyl)- 1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid p-toluenesulfonate hydrate.
| 【1】 Soejima, R.; Shimada, K.; TOSUFLOXACIN TOSYLATE < Prop INNM >. Drugs Fut 1989, 14, 6, 536. |
| 【2】 Kokei, T.; et al.; Chemical structure and physicochemical properties of (rac)-7-(3-amino-1-pyrrolidinyl)-6-fluoro-1-(2,4-difluorophenyl)-1,4- dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid p-toluensulfonate hydrate (T-3262). Iyakuhin Kenkyu 1988, 19, 682. |
| 【3】 Narita, H.; et al.; Pyridonecarboxylic acids as antibacterial agents IV. Yakugaku Zasshi 1986, 106, 795. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 15230 | ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylate | C17H10ClF3N2O3 | 详情 | 详情 | |
| (II) | 20938 | 3-pyrrolidinamine; 3-pyrrolidinylamine | C4H10N2 | 详情 | 详情 | |
| (III) | 20939 | ethyl 7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylate | C21H19F3N4O3 | 详情 | 详情 |
Extended Information