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【结 构 式】

【分子编号】20882

【品名】5-(2-oxiranylmethoxy)-3,4-dihydro-2(1H)-isoquinolinecarbaldehyde

【CA登记号】

【 分 子 式 】C13H15NO3

【 分 子 量 】233.26704

【元素组成】C 66.94% H 6.48% N 6% O 20.58%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

The formylation of 5-hydroxy-1,2,3,4-tetrahydroisoquinoline (I) with formamide (II) at 140 C gives N-formyl-5-hydroxy-1,2,3,4-tetrahydroisoquinoline (III), which is condensed with epichlorohydrin (IV) by means of NaOH in water yielding N-formyl-5-(2,3-epoxypropoxy)-1,2,3,4-tetrahydroisoquinoline (V). Finally, this compound is condensed with tert-butylamine (VI).

1 Knoll, A.-G. (Knoll AG); Isoquinoline derivatives. NL 7513301 .
2 Westermann, A.; Zimmermann, F.; Wuppermann, D.; Friedrich, L.; Raschack, M. (Knoll AG.); New isoquinoline derivatives. DE 2620179 .
3 Prous, J.; Castaner, J.; SOQUINOLOL MUCATE < Rec INNM >. Drugs Fut 1989, 14, 5, 439.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 20879 1,2,3,4-tetrahydro-5-isoquinolinol C9H11NO 详情 详情
(III) 20880 5-hydroxy-3,4-dihydro-2(1H)-isoquinolinecarbaldehyde C10H11NO2 详情 详情
(IV) 10146 Epichlorohydrin; 2-(Chloromethyl)oxirane 106-89-8 C3H5ClO 详情 详情
(V) 20882 5-(2-oxiranylmethoxy)-3,4-dihydro-2(1H)-isoquinolinecarbaldehyde C13H15NO3 详情 详情
(VI) 17895 2-Amino-2-methylpropane; tert-butylamine; 2-methyl-2-propanamine 75-64-9 C4H11N 详情 详情
Extended Information