6-fluoro-2-methyl-2,3-dihydro-4H-chromen-4-one -Drug Synthesis Database

【结构式】

【分子编号】20600

【品名】6-fluoro-2-methyl-2,3-dihydro-4H-chromen-4-one

【CA登记号】88754-96-5

【分子式】C₁₀H₉FO₂

【分子量】180.1786632

【元素组成】C 66.66% H 5.03% F 10.54% O 17.76%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

1) The cyclization of 4-fluorophenol (I) with chronic acid (II) by means of polyphosphonic acid (PPA) at 120 C gives 6-fluoro-2-methyl-chroman-4-one (III), which is then condensed with KCN and ammonium carbonate in hot acetamide.

参考文献中间体

合成目标

【1】 Ueda, K.; Nomura, K.; Tanaka, S.; Nakai, N. (Eisai Co., Ltd.); Hydantoin derivatives, processes for preparing them and pharmaceutical compositions containing them. EP 0193855; JP 61197581 .
【2】 Ueda, K.; et al. (Eisai Co., Ltd.); Treating complications of diabetes mellitus with hydantoin derivatives. BE 889698; DE 3128606; FR 2487353; GB 2080304; JP 57045185; US 4780472; US 4874869 .
【3】 Prous, J.; Castaner, J.; METHOSORBINIL. Drugs Fut 1989, 14, 4, 325.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	19639	4-fluorophenol	371-41-5	C₆H₅FO	详情	详情
(II)	20599	(E)-2-butenoic acid; crotonic acid	3724-65-0	C₄H₆O₂	详情	详情
(III)	20600	6-fluoro-2-methyl-2,3-dihydro-4H-chromen-4-one	88754-96-5	C₁₀H₉FO₂	详情	详情

Extended Information