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【结 构 式】 
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【分子编号】20352 【品名】5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-yl acetate 【CA登记号】 |
【 分 子 式 】C19H16N2O2 【 分 子 量 】304.34832 【元素组成】C 74.98% H 5.3% N 9.2% O 10.51% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The condensation of 9-acetoxyellipticine (I) with 2,3,4-tri-O-acetyl-beta-L-arabinopyranosyl bromide (II) by means of CdCO3 in refluxing nitromethane gives the corresponding tetraacetoxy derivative (III), which is then deprotected by treatment with dry ammonia in methanol.
| 【1】 Honda, T.; Nakanishi, T. (Suntory Ltd.); Ellipticine derivs.. AU 8545252; EP 0173462; JP 1986037799; JP 1987022794; JP 1987022795; JP 1987030795; US 4698423 . |
| 【2】 Hoshi, A.; Prous, J.; Castaner, J.; ELLIPRAVIN. Drugs Fut 1989, 14, 2, 116. |
| 【3】 Honda, T.; Kato, M.; Inoue, M.; Shimamoto, T.; Shima, K.; Nakanishi, T.; Yoshida, T.; Noguchi, T.; Synthesis and antitumor activity of quaternary ellipticine glycosides, a series of novel and highly active antitumor agents. J Med Chem 1988, 31, 7, 1295-305. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 20352 | 5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-yl acetate | C19H16N2O2 | 详情 | 详情 | |
| (II) | 20353 | (2S,3R,4S,5S)-3,5-bis(acetoxy)-2-bromotetrahydro-2H-pyran-4-yl acetate | C11H15BrO7 | 详情 | 详情 | |
| (III) | 20354 | 9-(acetoxy)-5,11-dimethyl-2-[(2R,3R,4S,5S)-3,4,5-tris(acetoxy)tetrahydro-2H-pyran-2-yl]-6H-pyrido[4,3-b]carbazol-2-ium bromide | C30H31BrN2O9 | 详情 | 详情 |
Extended Information