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【结 构 式】 
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【分子编号】20221 【品名】ethyl (3S)-1-[(2R)-2-amino-3-(1H-indol-3-yl)propanoyl]-3-benzyl-3-piperidinecarboxylate 【CA登记号】 |
【 分 子 式 】C26H31N3O3 【 分 子 量 】433.55056 【元素组成】C 72.03% H 7.21% N 9.69% O 11.07% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIII)The reaction of (X) with N-(tert-butoxycarbonyl)-D-tryptophan (XI) by means of DCC and HOBT in ethyl acetate affords the expected condensation product (XII), which is deprotected with HCl in hot ethanol giving compound (XIII) with its amino group free. The reaction of (XIII) with 2-(tert-butoxycarbonylamino)isobutyric acid (XIV) by means of DCC and HOBT as before yields the expected condensation product (XV), which is finally deprotected with HCl in methanol as before to give the target compound.
| 【1】 Maligres, P.E.; et al.; Preparation of (S)-3-carbethoxy-3-benzylpiperidine and the growth hormone secretagogue L-163,540. J Org Chem 1998, 63, 25, 9548. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (X) | 20217 | ethyl (3S)-3-benzyl-3-piperidinecarboxylate | C15H21NO2 | 详情 | 详情 | |
| (XI) | 16114 | N-alpha-t-BOC-L-tryptophan; (2S)-2-[(tert-butoxycarbonyl)amino]-3-(1H-indol-3-yl)propionic acid | 13139-14-5 | C16H20N2O4 | 详情 | 详情 |
| (XII) | 20220 | ethyl (3S)-3-benzyl-1-[(2R)-2-[(tert-butoxycarbonyl)amino]-3-(1H-indol-3-yl)propanoyl]-3-piperidinecarboxylate | C31H39N3O5 | 详情 | 详情 | |
| (XIII) | 20221 | ethyl (3S)-1-[(2R)-2-amino-3-(1H-indol-3-yl)propanoyl]-3-benzyl-3-piperidinecarboxylate | C26H31N3O3 | 详情 | 详情 | |
| (XIV) | 18471 | N-(tert-butoxycarbonyl)-2-methylalanine | 30992-29-1 | C9H17NO4 | 详情 | 详情 |
| (XV) | 20223 | ethyl (3S)-3-benzyl-1-[(2R)-2-([2-[(tert-butoxycarbonyl)amino]-2-methylpropanoyl]amino)-3-(1H-indol-3-yl)propanoyl]-3-piperidinecarboxylate | C35H46N4O6 | 详情 | 详情 |
Extended Information