【结 构 式】 |
【分子编号】20091 【品名】tert-butyl (1S)-1-[(hydroxyamino)carbonyl]-3-(methylsulfanyl)propylcarbamate 【CA登记号】 |
【 分 子 式 】C10H20N2O4S 【 分 子 量 】264.34588 【元素组成】C 45.44% H 7.63% N 10.6% O 24.21% S 12.13% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(IV)N-(tert-Butoxycarbonyl)-L-methionine (I) was converted to mixed anhydride (III) upon treatment with isobutyl chloroformate (II). Subsequent condensation of (III) with hydroxylamine gave hydroxamic acid (IV). Finally, the Boc group was cleared with trifluoroacetic acid in anisole to furnish the target methionine hydroxamate).
【1】 Lee, J.; Kang, M.K.; Chun, M.W.; Jo, Y.J.; Kwak, J.H.; Kim, S.; Methionine analogues as inhibitors of methionyl-tRNA synthetase. Bioorg Med Chem Lett 1998, 8, 24, 3511. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 17634 | (2S)-2-[(tert-butoxycarbonyl)amino]-4-(methylsulfanyl)butyric acid; N-alpha-t-BOC-L-methionine | 2488-15-5 | C10H19NO4S | 详情 | 详情 |
(II) | 13423 | 1-[(Chlorocarbonyl)oxy]-2-methylpropane; Isobutyl chloroformate;isobutyl carbonochloridate | 543-27-1 | C5H9ClO2 | 详情 | 详情 |
(III) | 20090 | N-(Tert-butoxycarbonyl)-L-methionine isobutoxycarbonyl anhydride | C15H27NO6S | 详情 | 详情 | |
(IV) | 20091 | tert-butyl (1S)-1-[(hydroxyamino)carbonyl]-3-(methylsulfanyl)propylcarbamate | C10H20N2O4S | 详情 | 详情 |
Extended Information