N''-[(1,4-dimethyl-1H-indol-2-yl)carbonyl]guanidine -Drug Synthesis Database

【结构式】

【分子编号】19963

【品名】N''-[(1,4-dimethyl-1H-indol-2-yl)carbonyl]guanidine

【CA登记号】

【分子式】C₁₂H₁₄N₄O

【分子量】230.26952

【元素组成】C 62.59% H 6.13% N 24.33% O 6.95%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

The methylaion of 4-methyl-1H-indole-2-carboxylic acid (I) with NaH and methyl iodide in DMF gives of 1,4-dimethylindole-2-carboxylic acid methyl ester (II), which is condensed with guanidine at 130 C, and treated with methanesulfonic acid in isopropanol.

参考文献中间体

合成目标

【1】 Kitano, M.; Nakano, K.; Yagi, H.; Ohashi, N.; Kojima, A.; Noguchi, T.; Miyagishi, A. (Sumitomo Pharmaceuticals Co., Ltd.); Indoloylguanidine derivs.. CA 2160600; EP 0708091; JP 1996208602 .
【2】 Kojima, A.; Kitano, M.; Miyagishi, A.; Noguchi, T.; Yagi, H.; Nakano, K.; Ohashi, N. (Sumitomo Pharmaceuticals Co., Ltd.); Indoloylguanidine derivs. as inhibitors of sodium-hydrogen exchange. CA 2121391; EP 0622356; JP 1995010839 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	19960	4-methyl-1H-indole-2-carboxylic acid		C₁₀H₉NO₂	详情	详情
(II)	19961	methyl 1,4-dimethyl-1H-indole-2-carboxylate		C₁₂H₁₃NO₂	详情	详情
(III)	14790	Guanidine	113-00-8	CH₅N₃	详情	详情
(IV)	19963	N''-[(1,4-dimethyl-1H-indol-2-yl)carbonyl]guanidine		C₁₂H₁₄N₄O	详情	详情

Extended Information